CAC_GL 40 Guidelines On Good Laboratory Practice In Pesticide Residue Analysis
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ID： |
327543A4614B44C583B5C6C2030D8F21 |
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文件大小(MB)： |
0.04 |
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页数： |
11 |
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文件格式： |
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日期： |
2004-12-24 |
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文本摘录（文本识别可能有误，但文件阅览显示及打印正常，pdf文件可进行文字搜索定位）：
CAC/GL 40 Page 1 of 11,GUIDELINES ON GOOD LABORATORY PRACTICE,IN PESTICIDE RESIDUE ANALYSIS,CAC/GL 401,1. INTRODUCTION,The ultimate goal in fair practice in international trade depends, among other things, on the,reliability of analytical results. This in turn, particularly in pesticide residues analysis, depends not only on,the availability of reliable analytical methods, but also on the experience of the analyst and on the,maintenance of "good laboratory practice in the analysis of pesticides". These guidelines define such good,analytical practice and may be considered in three inter-related parts:,The Analyst;,Basic Resources, and,The Analysis.,A discussion of each of these follows:,2. THE ANALYST,2.1 Residue analysis consists of a chain of procedures, most of which are known, or readily,understood, by a trained chemist, but because the analyte concentrations are in the range mg/kg to μg/kg,attention to detail is essential. The analyst in charge should have an appropriate professional qualification,and be experienced and competent in residue analysis. Staff must be fully trained and experienced in,correct use of apparatus and in appropriate laboratory skills. They must have an understanding of the,principles of pesticide residue analysis and the requirements of Analytical Quality Assurance (AQA),systems. They must understand the purpose of each stage in the method being used, the importance of,following the methods exactly as described and of noting any unavoidable deviations. They must also be,trained in the evaluation and interpretation of the data which they produce.,A record of training and experience must be kept for all members of staff.,2.2 When a laboratory for residue analysis is set up, the staff should spend some of their training,period in a well established laboratory where experienced advice and training is available. If the,laboratory is to be involved in the analysis for a wide range of pesticide residues it may be necessary for,the staff to gain experience in more than one established laboratory.,3. BASIC RESOURCES,3.1 The Laboratory,3.1.1 The laboratory and its facilities must be designed to allow tasks to be allocated to well defined,areas where maximum safety and minimum chance of contamination of samples prevail. Laboratories,should be constructed of and utilise materials resistant to chemicals likely to be used in the area. Thus,under such conditions, separate rooms would be designated for sample receipt and storage, for sample,preparation, for extraction and clean-up and for instrumentation used in the determinative step. The area,1 last revised in 1993.,CAC/GL 40 Page 2 of 11,used for extraction and clean-up must meet solvent laboratory requirements and all fume extraction,facilities must be of high quality. Receipt, storage and sample preparation can be handled in one and the,same room if only work at residue levels is being performed. The minimum requirements for pesticide,residue analytical facilities are maintenance of sample integrity and adequate provisions for personal,safety.,3.1.2 Laboratory safety must also be considered in terms of necessary and preferable conditions as it,must be recognised that the stringent working conditions enforced in residue laboratories in some parts of,the world could be totally unrealistic in others. No smoking, eating or drinking should be permitted in the,working area. The use or application of personal, domestic or industrial preparations for cleaning,decoration etc. should be minimized as they may cause contamination or other problems. Only small,volumes of solvents should be held in the working area and the bulk of the solvents stored separately,away from the main working area. The use of highly or chronically toxic solvents and reagents should be,minimised whenever possible. All waste solvent should be stored safely and disposed of both safely and,in an environmental protective manner.,3.1.3 The main working area should be designed and equipped for utilisation of a range of analytical,solvents. All equipment such as lights, macerators and refrigerators should be "spark free" or "explosion,proof". Extraction, clean-up and concentration steps should be carried out in a well ventilated area,preferably in fume cupboards.,3.1.4 Safety screens should be used when glassware is used under vacuum or pressure. There,should be an ample supply of safety glasses, gloves and other protective clothing, emergency washing,facilities and a spillage treatment kit. Adequate fire fighting equipment must be available. Staff must be,aware that many pesticides have acute or chronically toxic properties and therefore, great care……
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